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Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic. | LitMetric

Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic.

Adv Drug Deliv Rev

Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX, USA; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA. Electronic address:

Published: December 2021

AI Article Synopsis

  • mRNA vaccines, like those from Moderna and BioNTech/Pfizer, have played a crucial role in managing COVID-19, allowing a gradual shift away from strict social distancing and lockdowns.
  • This technology has gained significant public attention and research focus, opening the door for innovation in bionanotechnology.
  • Beyond COVID-19, mRNA vaccines hold promise for long-term solutions for various diseases, including influenza and AIDS, with ongoing studies exploring their future applications.

Article Abstract

mRNA vaccines have received major attention in the fight against COVID-19. Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to slowly ease the social distancing measures, mask requirements, and lockdowns that have been prevalent since early 2020. This past year's focused work on mRNA vaccines has catapulted this technology to the forefront of public awareness and additional research pursuits, thus leading to new potential for bionanotechnology principles to help drive further innovation using mRNA. In addition to alleviating the burden of COVID-19, mRNA vaccines could potentially provide long-term solutions all over the world for diseases ranging from influenza to AIDS. Herein, we provide a brief commentary based on the history and development of mRNA vaccines in the context of the COVID-19 pandemic. Furthermore, we address current research using the technology and future directions of mRNA vaccine research.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502079PMC
http://dx.doi.org/10.1016/j.addr.2021.114000DOI Listing

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