AI Article Synopsis
- The study aimed to find SARS-CoV-2 RNA in eye samples of patients who died from severe COVID-19.
- Samples were collected from the conjunctiva, aqueous humor, and vitreous humor of deceased patients and tested using RT-PCR.
- The results showed detectable viral RNA in 3.4% of samples, with positive findings in 1 conjunctival and 2 vitreous humor samples, indicating the potential for ocular involvement in severe COVID-19 cases.
Article Abstract
Purpose: To determine the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in postmortem ocular specimens of patients with severe COVID-19 disease.
Patients And Methods: Postmortem conjunctival (28 samples), aqueous humor (30 samples) and vitreous humor (30 samples) specimens were obtained bilaterally from the eyes of 15 deceased COVID-19 patients within one hour of death. The presence of viral RNA was evaluated in samples using Real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
Results: Positive RT-PCR SARS-COV-2 results were found in one conjunctival and 2 vitreous humor samples. All aqueous humor samples tested negative for the presence of SARS-COV-2 RNA. Of note, three positive samples were obtained from three different patients. The overall prevalence of positive RT-PCR ocular samples was 3.4% among all samples and 20% at the patient level.
Conclusion: SARS-CoV-2 RNA is detectable in postmortem conjunctival and vitreous humor samples of patients with severe COVID-19.
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| http://dx.doi.org/10.1080/09273948.2021.1980810 | DOI Listing |
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