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Pembrolizumab and chemotherapy in high-risk, early-stage, ER/HER2 breast cancer: a randomized phase 3 trial.
Nat Med
January 2025
University of California Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Addition of pembrolizumab to neoadjuvant chemotherapy followed by adjuvant pembrolizumab improved outcomes in patients with high-risk, early-stage, triple-negative breast cancer. However, whether the addition of neoadjuvant pembrolizumab to chemotherapy would improve outcomes in high-risk, early-stage, estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER/HER2) breast cancer remains unclear. We conducted a double-blind, placebo-controlled phase 3 study (KEYNOTE-756) in which patients with previously untreated ER/HER2 grade 3 high-risk invasive breast cancer (T1c-2 (≥2 cm), cN1-2 or T3-4, cN0-2) were randomly assigned (1:1) to neoadjuvant pembrolizumab 200 mg or placebo Q3W given with paclitaxel QW for 12 weeks, followed by four cycles of doxorubicin or epirubicin plus cyclophosphamide Q2W or Q3W.
View Article and Find Full Text PDFBenefits of Continuous Outpatient Orthopedic Consultations for Both Upper and Lower Body on the Mortality Rates of Hemodialysis Patients.
Cureus
December 2024
Orthopedic Surgery, Fukuoka University, Fukuoka, JPN.
Background: The purpose of the present observational study was to examine whether there is a difference in prognosis for hemodialysis patients with or without continued orthopedic outpatient visits over five years. Methods: One hundred and thirteen hemodialysis patients who visited the dialysis center of Takagi Hospital, Okawa, Japan, as of December 2017 were included in this study. Data were collected from the medical records until December 2022.
View Article and Find Full Text PDFHoneycomb-Shaped Collagen Aerogels Formed Using a Multichannel Hydrogel as the Template.
Langmuir
January 2025
Department of Chemistry and Applied Chemistry, Saga University, 1 Honjo, Saga City, Saga 840-8502, Japan.
This study introduces a novel method for fabricating multicavity, honeycomb-shaped collagen aerogels characterized by continuous pores. We have taken a unique approach to lyophilizing collagen hydrogels, which are UV-irradiated collagen solutions gelatinized in a carbonate buffer solution. The focus of this study was to investigate the effect of UV irradiation times on collagen solutions on collagen hydrogels and aerogels.
View Article and Find Full Text PDF[Rupture without Bleeding Secondary to Endotension After Thoracic Endovasular Aneurysm Repair:Report of a Case].
Kyobu Geka
December 2024
Department of Thoracic and Cardiovascular Surgery, Saga University, Saga, Japan.
We report a rare case of rupture without bleeding secondary to endotension after thoracic endovascular aneurysm repair. An 82-year-old woman had undergone multiple thoracic endovascular aortic repairs for a distal arch aneurysm. Due to the aneurysm enlargement, stent graft was eventually placed from the ascending aorta to just above the celiac artery after axillo-axillo-common carotid artery bypass.
View Article and Find Full Text PDFFeasibility and Efficacy of a Novel Mindfulness App Used With Matcha Green Tea in Generally Healthy Adults: Randomized Controlled Trial.
JMIR Mhealth Uhealth
December 2024
Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co Ltd, Saga, Japan.
Background: Mindfulness practices, such as breathing meditation (BM), reduce stress and enhance mood. One such practice is mindful eating, where a practitioner focuses on the five senses while eating or drinking. A novel set of prototypes has been developed, incorporating principles of mindful eating.
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