AI Article Synopsis
- - The study explored how fenofibrate might help reduce the negative impact of olanzapine on insulin resistance in female rats that were socially isolated after weaning, while still maintaining the antipsychotic effects of olanzapine.
- - After administering olanzapine and fenofibrate, the researchers evaluated behavior, neurotransmitter levels, and various biochemical markers related to insulin resistance, lipid profiles, and inflammation.
- - Results indicated that fenofibrate not only improved behavioral and biochemical issues caused by social isolation and olanzapine but also effectively countered olanzapine's adverse effects on insulin resistance and adiponectin levels.
Article Abstract
The present work was designed to investigate whether fenofibrate could ameliorate olanzapine deleterious effect on insulin resistance via its effect on fibroblast growth factor-21 (FGF-21)-adiponectin axis without affecting olanzapine antipsychotic effect in postweaning socially isolated reared female rats. Treatment with olanzapine (6 mg/kg, intraperitoneally) or fenofibrate (100 mg/kg, orally) have been started 5 weeks after isolation, then behavioral tests, hippocampal content of neurotransmitters, and brain-derived neurotrophic factor (BDNF) were assessed. Moreover, insulin resistance, lipid profile, FGF-21, adiponectin, inflammatory, and oxidative stress markers of adipose tissue were assessed. Treatment of isolated-reared animals with olanzapine, or fenofibrate significantly ameliorated the behavioral and biochemical changes induced by postweaning social isolation. Co-treatment showed additive effects in improving hippocampal BDNF level. Besides, fenofibrate reduced the elevation in weight gain, adiposity index, insulin resistance, lipid profile, and FGF-21 level induced by olanzapine treatment. Also, fenofibrate increased adiponectin level which was reduced upon olanzapine treatment. Moreover, fenofibrate improved both adipose tissue oxidative stress and inflammatory markers elevation as a result of olanzapine treatment. Fenofibrate could ameliorate olanzapine-induced insulin resistance without affecting its central effect in isolated reared rats via its action on FGF-21-adiponectin axis.
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| http://dx.doi.org/10.1097/FBP.0000000000000656 | DOI Listing |
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