AI Article Synopsis
- Seven different versions of a specific amphiphilic gemini monomer were created and tested for their ability to form a bicontinuous cubic lyotropic liquid crystal phase.
- Four of these versions successfully formed a Q phase when combined with glycerol or water, and this phase could be cross-linked while maintaining its nanoporous structure.
- One of the versions demonstrated a well-organized Q phase that has a broader range of conditions in which it remains stable compared to the original monomer.
Article Abstract
Seven homologues of an amphiphilic gemini monomer were synthesized and screened for the ability to form a bicontinuous cubic (Q) lyotropic liquid crystal phase. Four of these homologues form a Q phase with glycerol or water that can be cross-linked with retention of the nanoporous structure, with one exhibiting a well-ordered Q phase with a wider phase window than the parent monomer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d1sm01100f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and Mesomorphic Properties of Geometric and Conformation-Modulated Amphiphilic β-Cyclodextrin Liquid Crystals.
Molecules
November 2024
Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
This study explores the liquid crystalline properties of novel amphiphilic β-cyclodextrin derivatives functionalized with seven oligoethylene glycol chains at the primary face, terminated with either an O-methyl or an O-cyanoethyl group, and fourteen hydrophobic aliphatic chains (elaidic or oleic acids) at the secondary face. These derivatives were designed to study the impact of chain conformation and terminal group polarity on their mesomorphic behavior. Thermal, microscopic, and X-ray diffraction studies revealed that the elaidic derivatives form columnar hexagonal mesophases, with the O-cyanoethyl derivative undergoing a slow, temperature-dependent transition to a bicontinuous cubic phase.
View Article and Find Full Text PDFLow-frequency Raman spectroscopy as a new tool for understanding the behaviour of ionisable compounds in dispersed mesophases.
J Colloid Interface Sci
December 2024
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville 3052, VIC Australia. Electronic address:
Hypothesis: Low-frequency Raman (LFR) spectroscopy is proposed as a novel non-destructive methodology to probe pH-related phase transitions in self-assembled lipid particles. In this case, dispersed lipid mesophases were composed of ionisable oleic acid (OA) or nicergoline (NG) in monoolein (MO). The sensitivity of LFR spectroscopy to low-energy intermolecular vibrations was hypothesised to be due to structural transformation in ionisable dispersed mesophases upon changes in pH.
View Article and Find Full Text PDFComparing the lipid self-assembly behaviour and fatty acid composition of plant-based drinks to bovine milk during digestion.
Food Chem
February 2025
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia. Electronic address:
In this study, a static in-vitro digestion model was coupled with synchrotron small-angle X-ray scattering (SAXS) to compare the lipid self-assembly behaviour of plant-based drinks and bovine milk during digestion. The diffraction profiles were combined with principal component analysis (PCA) of the fatty acid (FA) composition during digestion. Half of the plant-based drinks were found to form an inverse micellar cubic phase which is substantially different from the inverse hexagonal and bicontinuous cubic phases determined in bovine milk during digestion.
View Article and Find Full Text PDFDesign of Functional Gyroid Minimal Surfaces Transporting Proton Based Solely on Surface Hopping Conduction Mechanism.
Macromol Rapid Commun
November 2024
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, 184-8588, Japan.
Surface proton hopping conduction (SPHC) mechanisms is an important proton conduction mechanism in conventional polymer electrolytes, along with the Grotthuss and vehicle mechanisms. Due to the small diffusion coefficient of protons in the SPHC mechanism, few studies have focused on the SPHC mechanism. Recently, it has been found that a dense alignment of SO groups significantly lowers the activation energy in the SPHC mechanism, enabling fast proton conduction.
View Article and Find Full Text PDFClarithromycin-tailored cubosome: A sustained release oral nano platform for evaluating antibacterial, anti-biofilm, anti-inflammatory, anti-liver cancer, biocompatibility, ex-vivo and in-vivo studies.
Int J Pharm
December 2024
Department of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said 42515, Egypt. Electronic address:
The clinical implication of clarithromycin (CLT) is compromised owing to its poor solubility and, subsequently, bioavailability, unpalatable taste, rapid metabolism, short half-life, frequent dosing, and adverse effects. The present investigation provides an innovative sustained-release oral drug delivery strategy that tackles these challenges. Accordingly, CLT was loaded into a cubosome, a vesicular system with a bicontinuous cubic structure that promotes solubility and bioavailability, provides a sustained release system combating short half-life and adverse effects, masks unpleasant taste, and protects the drug from destruction in gastrointestinal tract (GIT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!