Isopimarane-type diterpenoids from the rhizomes of L. and their biological activities.

Fourteen isopimarane diterpenoids (-) were isolated from the rhizomes of , including four new compounds (-). The isolated secondary metabolites were identified through analysis of spectroscopic (1 D and 2 D NMR) and mass spectrometric data, together with X-ray diffraction studies. Compounds -, -, and showed strong antimalarial activities, with IC values in the range of 1.46-3.99 g/mL. Moreover, compounds , , , and showed cytotoxicity against KB cell line with IC values in the range of 6.13-38.2 g/mL, while compounds , , and showed cytotoxicity against MCF-7 cell line with IC values in the range of 11.75-47.4 g/mL. Eventually, the isolated compounds were screened against six bacterial strains and , demonstrating weak to moderate activities.