Thifluzamide is widely used fungicide and frequently detected in aquatic system. In this study, the toxicity of fungicide thifluzamide to non-targeted aquatic organisms was investigated for neuroendocrine disruption potentials. Here, zebrafish embryos were exposed to a series of concentrations of thifluzamide for 6 days. The results showed that both the development of embryos/larvae and the behavior of hatched larvae were significantly affected by thifluzamide. Importantly, the decreased activity of acetylcholinesterase (AchE) and the increased contents of neurotransmitters such as serotonin (5-HT) and norepinephrine (NE), along with transcriptional changes of nervous system related genes were observed following 4 days exposure to thifluzamide. Besides, the decreased contents of triiodothyronine (T3) and thyroxine (T4) in whole body, as well as significant expression alteration in hypothalamic-pituitary-thyroid (HPT) axis associated genes were discovered in zebrafish embryos after 4 days of exposure to thifluzamide. Our results clearly demonstrated that zebrafish embryos exposed to thifluzamide could disrupt neuroendocrine, compromise behavior and induce developmental abnormality, suggesting impact of this fungicide on developmental programming in zebrafish.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00204-021-03158-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the Cytotoxicity of a Newly Developed Obturating Material for Pulpectomy in Primary Teeth Using Embryonic Toxicology, Brine Shrimp Lethality, and MTT Assay: An In Vitro Study.
Eur J Dent
March 2025
Division of Pediatric Dentistry, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Objective: The search for an ideal obturating material has taken precedence due to the revolution of the materials used in pediatric endodontics. With zinc oxide, calcium hydroxide, and metronidazole as its core constituents, an unique obturating material was developed. To aid in the healing process, the material should be biocompatible and most importantly it should not have any negative consequences.
View Article and Find Full Text PDFEffects of combined stressors to TCDD and high temperature on HSP/CYPs signaling in the zebrafish embryos/larvae.
Environ Pollut
March 2025
College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, 028000, China; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology. Electronic address:
Global warming causes the release of dioxin-like deposits and increases geographical migration, increasing the risk of exposure for humans and animals. In this experiment, we used CYP1A transgenic zebrafish Tg (cyp1a: mCherry) and liver fluorescent transgenic zebrafish Tg (fabp10: Ps Red) as an animal model and exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) at 26 °C and 30 °C, respectively. Morphological changes, histological changes, transcriptome and related genes expression were detected.
View Article and Find Full Text PDFZebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3-mediated IFN I response.
J Immunol
March 2025
School of Life Science, Nanchang University, Nanchang, China.
Transactive response DNA binding protein 43 kD (TDP43), encoded by the tardbp gene, is a member of heterogenous nuclear ribonucleoproteins family. In this study, a gradual upregulation of TDP43 messenger RNA was observed in either Ctenopharyngodon idella kidney cells or zebrafish following stimulation with B-DNA, grass carp reovirus, or spring viremia of carp virus. Moreover, grass carp reovirus stimulation enhances the dimerization, phosphorylation, and cytoplasm-to-nucleus translocation of TDP43 in zebrafish (DrTDP43).
View Article and Find Full Text PDFEmbryotoxicity Evaluation of Novel Synthetic Cannabinoid 4F-MDMB-BUTICA Using Zebrafish Embryos.
J Appl Toxicol
March 2025
Department of Molecular Biology and Genetics, Science Faculty, Atatürk University, Erzurum, Türkiye.
Detailed studies on the embryotoxic and teratogenic effects of synthetic cannabinoids known to be abused are very limited. The present study aimed to evalutate the possible embryotoxic, teratogenic, behavioral, and molecular effects of 4F-MDMB-BUTICA, a new generation synthetic cannabinoid, using zebrafish embryos. The zebrafish embryos were exposed to the cannabinoid at 0.
View Article and Find Full Text PDFDeltaC and DeltaD ligands play different roles in the segmentation clock dynamics.
Nat Commun
March 2025
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
The vertebrate segmentation clock drives periodic somite segmentation during embryonic development. Her1 and Her7 clock proteins generate oscillatory expression of their own genes as well as that of deltaC in zebrafish. In turn, DeltaC and DeltaD ligands activate Notch signaling, which then activates transcription of clock genes in neighboring cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!