The association between sarcopenia and functional outcomes after hospital discharge among critically ill surgical patients.

Wariya Vongchaiudomchoke Benjaporn Sathitkarnmanee Chayanan Thanakiattiwibun Sunit Jarungjitaree Onuma Chaiwat

Asian J Surg

Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Published: July 2022

The study looked at how sarcopenia (muscle loss) impacts recovery for patients over 65 in the surgical intensive care unit (SICU).
Researchers used specific tests to assess muscle mass and strength and evaluated patients' abilities to perform daily activities after discharge.
Findings showed that sarcopenia, along with the length of mechanical ventilation and hospital stay, predicted worse functional outcomes and higher risk of mortality within 120 days.

Background: To determine the association between sarcopenia in surgical intensive care unit (SICU) patients and long-term functional outcomes.

Method: This prospective, cohort study enrolled patients aged >65 years admitted to SICUs at the tertiary care hospital. Their muscle mass and strength were measured by bioelectrical impedance vector analysis (BIVA) and handgrip-strength or manual-muscle-strength tests. The functional outcomes were evaluated with the Thai version of the Barthel index for activities of daily living (ADL).

Results: 120 patients were enrolled. A multivariate analysis identified 3 independent predictors associated with poor functional outcomes (ADL scores ≤70) at one month after hospital discharge including sarcopenia (adjusted odds ratio [aOR]: 3.33; 95% confidence interval [CI]: 1.25-8.87); duration of mechanical ventilation (aOR: 1.19; 95% CI: 1.02-1.38); and length of hospital stay (aOR: 1.05; 95% CI: 1.01-1.10). Cox proportional-hazards regression models found that sarcopenia (adjusted hazard ratio [aHR]: 2.07; 95% CI: 1.02-4.22) and admission severity (aHR: 1.13; 95% CI: 1.04-1.23) were predictors of 120-day mortality.

Conclusions: Sarcopenia was an independent predictor of poor functional outcomes at one month after hospital discharge.

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http://dx.doi.org/10.1016/j.asjsur.2021.09.012	DOI Listing

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