AI Article Synopsis
- Childhood noninfectious uveitis can cause serious eye problems, with idiopathic chronic anterior uveitis and juvenile idiopathic arthritis-associated uveitis being the most common types.
- The inflammation is a result of the immune system reacting to antigens in the eye, and to diagnose it, doctors assess the eye's anatomy, disease activity, and complications.
- While initial treatment usually involves glucocorticoids, ongoing management often requires other medications like methotrexate or anti-TNF therapies to avoid side effects and ensure better vision outcomes.
Article Abstract
Childhood noninfectious uveitis leads to sight-threatening complications. Idiopathic chronic anterior uveitis and juvenile idiopathic arthritis-associated uveitis are most common. Inflammation arises from an immune response against antigens within the eye. Ophthalmic work-up evaluates anatomic involvement, disease activity, ocular complications, and disease course. Local and/or systemic glucocorticoids are initial treatment, but not as long-term sole therapy to avoid glucocorticoids-induced toxicity or persistent ocular inflammation. Children with recurrent, refractory, or severe disease require systemic immunosuppression with methotrexate and/or anti-tumor necrosis factor monoclonal antibody medications (adalimumab, infliximab). Goals of early detection and treatment are to optimize vision in childhood uveitis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511507 | PMC |
| http://dx.doi.org/10.1016/j.rdc.2021.07.005 | DOI Listing |
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