AI Article Synopsis
- Anorexia nervosa (AN) is a genetic and complex disorder often accompanied by other mental health issues, making treatment challenging.
- Recent genetic research has improved the understanding of polygenic diseases and revealed potential connections between AN and other disorders.
- The review highlights findings from genome-wide association studies (GWAS), discusses relevant metabolic and psychiatric pathways, and the overlap of AN with various traits and conditions.
Article Abstract
Anorexia nervosa (AN) is a complex disorder with a strong genetic component. Comorbidities are frequent and there is substantial overlap with other disorders. The lack of understanding of the molecular and neuroanatomical causes has made it difficult to develop effective treatments and it is often difficult to treat in clinical practice. Recent advances in genetics have changed our understanding of polygenic diseases, increasing the possibility of understanding better how molecular pathways are intertwined. This review synthetizes the current state of genetic research providing an overview of genome-wide association studies (GWAS) findings in AN as well as overlap with other disorders, traits, pathways, and imaging results. This paper also discusses the different putative global pathways that are contributing to the disease including the evidence for metabolic and psychiatric origin of the disease.
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| http://dx.doi.org/10.1016/j.jgg.2021.09.005 | DOI Listing |
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