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Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants. | LitMetric

Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants.

Plant Physiol

Departamento de Biología Molecular y Bioquímica, Universidad de Málaga. Edificio I+D, Málaga 29071, Spain.

Published: January 2022

AI Article Synopsis

Article Abstract

Phenylalanine (Phe) is the precursor of essential secondary products in plants. Here we show that a key, rate-limiting step in Phe biosynthesis, which is catalyzed by arogenate dehydratase, experienced feedback de-regulation during evolution. Enzymes from microorganisms and type-I ADTs from plants are strongly feedback-inhibited by Phe, while type-II isoforms remain active at high levels of Phe. We have found that type-II ADTs are widespread across seed plants and their overproduction resulted in a dramatic accumulation of Phe in planta, reaching levels up to 40 times higher than those observed following the expression of type-I enzymes. Punctual changes in the allosteric binding site of Phe and adjacent region are responsible for the observed relaxed regulation. The phylogeny of plant ADTs evidences that the emergence of type-II isoforms with relaxed regulation occurred at some point in the transition between nonvascular plants and tracheophytes, enabling the massive production of Phe-derived compounds, primarily lignin, a hallmark of vascular plants.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774845PMC
http://dx.doi.org/10.1093/plphys/kiab454DOI Listing

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