Hi1a is a venom peptide from the Australian funnel-web spider with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acute ischemic events. Herein, we describe the total synthesis of Hi1a using native chemical ligation. The synthetic peptide was successfully folded and exhibited similar inhibitory activity on ASIC1a to recombinant Hi1a.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c03112 | DOI Listing |
Publication Analysis
Top Keywords
total synthesis
8
hi1a
5
synthesis spider-venom
4
spider-venom peptide
4
peptide hi1a
4
hi1a hi1a
4
hi1a venom
4
venom peptide
4
peptide australian
4
australian funnel-web
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!