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3D liver tumor microenvironment models for immune cell therapy optimization. | LitMetric

AI Article Synopsis

Article Abstract

Despite diagnostic and therapeutic advances, liver cancer kills more than 18 million people every year worldwide, urging new strategies to model the disease and to improve the current therapeutic options. tumor models of human cancer continue to evolve, and they represent an important screening tool. However, there is a tremendous need to improve the physiological relevance and reliability of these models to fulfill today's research requirements for better understanding of cancer progression and treatment options at different stages of the disease. This review describes the hepatocellular carcinoma microenvironmental characteristics and illustrates the current immunotherapy strategy to fight the disease. Moreover, we present a recent collection of 2D and 3D liver cancer models and address the next generation of systems recapitulating the tumor microenvironment complexity in more detail.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492081PMC
http://dx.doi.org/10.1063/5.0057773DOI Listing

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