Hyperuricemia is a pathological condition associated with risk factors of cardiovascular disease. In this study, three genetic polymorphisms were genotyped as predisposing factors of hyperuricemia. A total of 860 Mexicans (129 cases and 731 controls) between 18 and 25 years of age were genotyped for the (Q191K), (517G>A), and (518T>C) polymorphisms, as predisposing factors of hyperuricemia. Biochemical parameters were measured by spectrophotometry, while genetic polymorphisms were analyzed by real-time PCR. An analysis of the risk of hyperuricemia in relation to the variables studied was carried out using a logistic regression. Male sex, being overweight or obese, having hypercholesterolemia or having hypertriglyceridemia were factors associated with hyperuricemia ( ≤ 0.05). The polymorphism was associated with hyperuricemia (OR = 2.43, 95% CI: 1.41-4.17, = 0.001) and hypercholesterolemia (OR = 4.89, 95% CI: 1.54-15.48, = 0.003), employing a dominant model, but only in male participants. : The (Q191K) polymorphism increases the risk of hyperuricemia and hypercholesterolemia in young Mexican males.
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| http://dx.doi.org/10.12688/f1000research.46399.2 | DOI Listing |
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