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| http://dx.doi.org/10.3389/fmicb.2021.741387 | DOI Listing |
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Tailoring formulation for enhanced phage therapy in canine otitis externa: a cocktail approach targeting Pseudomonas aeruginosa and Staphylococcus pseudintermedius.
Vet Microbiol
December 2024
Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1, Gwanak-ro, Seoul 08826, Republic of Korea. Electronic address:
Canine otitis externa, characterized by the involvement of diverse bacterial species, notably Pseudomonas aeruginosa and Staphylococcus pseudintermedius, necessitates antibiotic administration as the primary therapeutic approach; however, prolonged treatment often precipitates antibiotic resistance. Therefore, the application of bacteriophages as antimicrobial agents has been of interest recently. However, phage therapy has limitations; its efficacy depends on the lytic capacity of the phage and the emergence of phage resistance, which can be overcome by using phage cocktails.
View Article and Find Full Text PDFTargeted dual-receptor phage cocktail against : insights into phage-host interactions and resistance mechanisms.
Front Microbiol
December 2024
Department of Food and Animal Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Introduction: is a notorious foodborne pathogen, frequently contaminating powdered infant formula and causing life-threatening diseases in infants. The escalating emergence of antibiotics-resistant mutants has led to increased interest in using bacteriophage as an alternative antimicrobial agent.
Methods: Two phages, CR8 and S13, were isolated from feces and soil samples and their morphology, physiology, and genomics were characterized.
Detection of Phage's Lytic Activity Against Carbapenemase-Producing Klebsiella pneumoniae Isolates Using a High-Throughput Microbroth Growth Inhibition Assay.
Infect Dis Ther
December 2024
Clinical Microbiology Laboratory, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Article Synopsis
- The study developed a microbroth assay to evaluate the host range and lytic activity of phages against carbapenemase-producing K. pneumoniae isolates, addressing limitations of the traditional agar overlay method.
- The host range was tested on 11 specific phages using various concentrations and bacterial inocula, with analysis of growth inhibition over 6 and 24 hours.
- Results showed significant differences in growth inhibition among phages and identified specific cutoffs for lysis detection, demonstrating the microbroth assay's effectiveness and reliability.
Comparative metagenomics of microbial communities and resistome in southern farming systems: implications for antimicrobial stewardship and public health.
Front Microbiol
November 2024
EzBiome Inc., Gaithersburg, MD, United States.
Agricultural practices significantly influence microbial diversity and the distribution of virulence and antimicrobial resistance (AMR) genes, with implications for ecosystem health and food safety. This study used metagenomic sequencing to analyze 60 samples (30 per state) including water, soil, and manure (10 each) from Alabama (a mix of cattle and poultry sources) and Tennessee (primarily from cattle). The results highlighted a rich microbial diversity, predominantly comprising Bacteria (67%) and Viruses (33%), with a total of over 1,950 microbial species identified.
View Article and Find Full Text PDFThe antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins.
J Biol Chem
December 2024
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address:
The human gastrointestinal tract is a competitive environment inhabited by dense polymicrobial communities. Bacteroides, a genus of Gram-negative anaerobes, are prominent members of this ecological niche. Bacteroides spp.
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