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A 1:1 flavone cocrystal with cyclic trimeric perfluoro--phenyl-enemercury.
Acta Crystallogr E Crystallogr Commun
June 2024
Department of Chemistry New Mexico Highlands University,Las Vegas New Mexico 87701 USA.
The title compound, systematic name tris-(μ-perfluoro--phenyl-ene)(μ-3-phenyl-4-chromen-4-one)--trimercury, [Hg(CF)(CHO)], crystallizes in the monoclinic 2/ space group with one flavone (FLA) and one cyclic trimeric perfluoro--phenyl-enemercury (TPPM) mol-ecule per asymmetric unit. The FLA mol-ecule is located on one face of the TPPM acceptor and is linked in an asymmetric coordination of its carbonyl oxygen atom with two Hg centers of the TPPM macrocycle. The angular-shaped complexes pack in zigzag chains where they stack two alternating TPPM-TPPM and FLA-FLA stacking patterns.
View Article and Find Full Text PDFBenzopyrone, a privileged scaffold in drug discovery: An overview of FDA-approved drugs and clinical candidates.
Med Res Rev
September 2024
Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India.
Natural products have always served as an important source of drugs for treating various diseases. Among various privileged natural product scaffolds, the benzopyrone class of compounds has a substantial presence among biologically active compounds. One of the pioneering anticoagulant drugs, warfarin approved in 1954 bears a benzo-α-pyrone (coumarin) nucleus.
View Article and Find Full Text PDFRecent advancements in multifaceted roles of flavonoids in plant-rhizomicrobiome interactions.
Front Plant Sci
January 2024
School of Basic Science, Department of Botany, Central University of Punjab, Bhatinda, Punjab, India.
The rhizosphere consists of a plethora of microbes, interacting with each other as well as with the plants present in proximity. The root exudates consist of a variety of secondary metabolites such as strigolactones and other phenolic compounds such as coumarin that helps in facilitating communication and forming associations with beneficial microbes in the rhizosphere. Among different secondary metabolites flavonoids (natural polyphenolic compounds) continuously increasing attention in scientific fields for showing several slews of biological activities.
View Article and Find Full Text PDF7,8-dihydroxyflavone displayed antioxidant effect through activating HO-1 expression and inhibiting caspase-3/PARP activation in RAW264.7 cells.
J Biochem Mol Toxicol
January 2024
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
Article Synopsis
- Flavonoids, particularly 7,8-dihydroxyflavone (7,8-DHF) and 7-hydroxyflavone (7-HF), were studied for their antioxidant properties in RAW264.7 cells subjected to oxidative stress.
- Using various assays, the study found that 7,8-DHF exhibited stronger antioxidant effects than 7-HF by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while enhancing superoxide dismutase (SOD) activity.
- The mechanisms revealed that 7,8-DHF inhibited cellular damage pathways and boosted protective proteins, indicating its potential as a drug to combat oxidative stress injuries.
Effectiveness of the Fungal Metabolite 3--Methylfunicone towards Canine Coronavirus in a Canine Fibrosarcoma Cell Line (A72).
Antibiotics (Basel)
November 2022
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.
Canine coronavirus (CCoV), an alphacoronavirus, may cause self-limiting enteric disease in dogs, especially in puppies. The noteworthy plasticity of coronaviruses (CoVs) occurs through mutation and recombination processes, which sometimes generate new dangerous variants. The ongoing SARS-CoV-2 pandemic and the isolation of a novel canine-feline recombinant alphacoronavirus from humans emphasizes the cross-species transmission ability of CoVs.
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