AI Article Synopsis
- Gastric cancer is a major cause of cancer deaths in Taiwan, ranking as the sixth leading cause of mortality for both genders, prompting the need for analysis of trends in incidence.
- A study using the Taiwan Cancer Registry found that gastric cancer rates have been decreasing annually for both males (-2.58%) and females (-2.14%), with higher incidence rates observed in older age groups.
- There is a notable correlation between the decrease in gastric cancer rates and the increasing use of antibiotic therapy for infection, suggesting that eradication efforts may be effective.
Article Abstract
Background: Gastric cancer remains a leading cause of cancer death worldwide. In Taiwan, gastric cancer is the sixth leading cause of cancer mortality in both males and females.
Aim: To evaluate secular trends in gastric cancer incidence according to age, sex, and () treatment in Taiwan.
Methods: In this population-based study, we used the national Taiwan Cancer Registry database. Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan. Pearson's product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for infection.
Results: The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females. However, the decreasing trends differed by sex, with an annual percent change of -2.58% in males and -2.14% in females. The age-specific incidence rates increased with age. Within the same age group, more recent time periods showed lower incidence rates than greater time periods. Similarly, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for infection during 2005 to 2016 ( = 0.72).
Conclusion: We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan. These results support eradication programs in Taiwan.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473596 | PMC |
| http://dx.doi.org/10.3748/wjg.v27.i34.5764 | DOI Listing |
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