AI Article Synopsis
- A new method using titanium(IV) facilitates the reaction of diaryl-substituted methanols and cyclopropanol derivatives, leading to the formation of γ,γ-diaryl esters.
- These reactions are effective and yield moderate to good results, making them valuable for synthetic applications.
- The resulting esters can be used to modify complex molecules from drugs like fenofibrate and isoxepac, as well as in synthesizing a precursor for the antidepressant Zoloft.
Article Abstract
A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols with a cyclopropanol derivative was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters in moderate to good yields, which could be applied to the functionalization of complex molecules derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft.
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| http://dx.doi.org/10.1021/acs.joc.1c01790 | DOI Listing |
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