[Effect of 's type Ⅱ inhibition acupuncture on chronic migraine and serum 5-HT, VEGF, CGRP].

Objective: To observe the clinical efficacy of 's type Ⅱ inhibition acupuncture for chronic migraine, and explore the possible mechanism.

Methods: A total of 120 patients with chronic migraine were randomized into an observation group (60 cases, 3 cases dropped off) and a control group (60 cases, 2 cases dropped off). In the control group, flunarizine hydrochloride capsule was taken orally, 5 mg each time, once a day. In the observation group, 's typeⅡ inhibition acupuncture was applied at Erheliao (TE 22), Shousanli (LI 10), Hegu (LI 4), Yangbai (GB 14), Tongziliao (GB 1), Zusanli (ST 36) ect., once every other day. The treatment was given 4 weeks in the two groups. Before and after treatment, the migraine clinical symptom score, cerebral hemodynamics indexes (blood flow velocity of arterior cerebral artery [ACA], posterior cerebral artery [PCA], bilateral middle cerebral artery [MCA] and basilar artery [BA]), serum related indexes (levels of 5-hydroxytryptamine [5-HT], vascular endothelial growth factor [VEGF] and calcitonin gene-related peptide [CGRP]) and migraine specific quality of life questionnaire (MSQ) score were observed in the two groups, and the clinical effect was evaluated.

Results: The total effective rate in the observation group was 93.0% (53/57), which was higher than 79.3% (46/58) in the control group (<0.05). After treatment, the number of headache attack was reduced, duration time was shortened, and the scores of pain intensity and concomitant symptom, cerebral hemodynamics indexes (blood flow velocity of ACA, PCA, MCA and BA) and serum levels of VEGF and CGRP were lower than before treatment in the two groups (<0.05, <0.01), and those in the observation group were lower than the control group (<0.05). After treatment, the serum levels of 5-HT and MSQ scores of functional limitation, dysfunction and emotion were higher than before treatment in the two groups (<0.05), and those in the observation group were higher than the control group (<0.05).

Conclusion: 's type Ⅱ inhibition acupuncture could reduce frequency of migraine attack and duration time, improve pain intensity, cerebral blood flow velocity and quality of life for patients with chronic migraine, its mechanism may be related to regulating serum levels of 5-HT, CGRP and VEGF.