VARIANTS OF IL1 (C3954T, RS1143634), PON1 (C108T, RS705379) GENES AS PROGNOSTIC MARKERS OF OSTEOMYELITIS RISK AND ITS COMPLICATIONS.

The aim of the work was to study the effect of IL1Β (C3954T, rs1143634), PON1 (C108T, rs705379) gene variants on the risk of bacterial osteomyelitis development and its complicated course. The study involved 56 patients with osteomyelitis - 20 with not complicated (non-recurrent) course after treatment and 36 with complicated (recurrent) course. The data of population frequencies for the European population, obtained from the open database of "1000 Genomes project", were used as a control group. There was significantly increased distribution frequency of genotype 3954TT of IL1Β in patients with uncomplicated course compared to the control group (χ2=6.05, p=0.014, OR=4.99 (1.55-16.07)). And was found increased of minor genotype 108TT of PON1 frequency in patients with osteomyelitis compared to control group (χ2=4.38, p=0.036, OR=1.85(1.03-3.33)). There were found gender differences in the clinical effects of IL1Β gene variant: in men, the prevalence of genotype 3954CC was significantly to be increased in the patient with complicated osteomyelitis; genotype 3954CT was associated with a reduced risk of osteomyelitis and its complications developing, while in women was found the association of genotype 3954TT with an uncomplicated course of the disease. In conclusion, this study suggests that the variants of IL1В and PON1 genes associated with the risk of developing bacterial osteomyelitis and its complicated course and can be used as a prognostic marker for developing personalized prevention strategies.