We run pool boiling experiments with a dielectric fluid (FC-72) on Earth and on board an ESA parabolic flight aircraft able to cancel the effects of gravity, testing both highly wetting microstructured surfaces and plain surfaces and applying an external electric field that creates gravity-mimicking body forces. Our results reveal that microstructured surfaces, known to enhance the critical heat flux on Earth, are also useful in microgravity. An enhancement of the microgravity critical heat flux on a plain surface can also be obtained using the electric field. However, the best boiling performance is achieved when these techniques are used together. The effects created by microstructured surfaces and electric fields are synergistic. They enhance the critical heat flux in microgravity conditions up to 257 kW/m, which is even higher than the value measured on Earth on a plain surface (i.e., 168 kW/m). These results demonstrate the potential of this synergistic approach toward very compact and efficient two-phase heat transfer systems for microgravity applications.
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http://dx.doi.org/10.1038/s41526-021-00167-3 | DOI Listing |
Int J Physiol Pathophysiol Pharmacol
December 2024
Gene Expression and Signaling Lab, Department of Zoology, Mahatma Gandhi Central University Motihari Motihari, Bihar 845401, India.
Objective: The Heat Shock Protein 70 (HSP70) family is a highly conserved group of molecular chaperones essential for maintaining cellular homeostasis. These proteins are necessary for protein folding, assembly, and degradation and involve cell recovery from stress conditions. HSP70 proteins are upregulated in response to heat shock, oxidative stress, and pathogenic infections.
View Article and Find Full Text PDFSci Rep
January 2025
Thermal and Energetic Systems Studies Laboratory (LESTE), LR99ES31, College of Engineering, University of Monastir, 5000, Monastir, Tunisia.
Using the RANS approach with the standard k-ω turbulence model, this study offers a novel investigation into the dynamic and thermal properties of turbulent impinging jet arrays. Our study examines the combined effect of the number of jets (N) and the jet-jet spacing (S) on flow mechanisms and heat transfer performance, which is unique compared to previous research that frequently focuses on the individual effects of parameters. Through the investigation of the turbulent kinetic energy, friction coefficient, velocity contours, streamlines, pressure contours, and local and mean Nusselt numbers, we provide important information about how these parameters impact flow dynamics.
View Article and Find Full Text PDFBiochem Pharmacol
January 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240 PR China; National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240 PR China. Electronic address:
Multiple organ dysfunction syndrome (MODS) is the major cause of mortality of patients in intensive care units. The elusive mechanisms of tissue damage in MODS and limited therapeutic options encourage us to seek effective therapies to MODS. PANoptosis has recently been proven to be the key player in both heat stress and sepsis-mediated MODS.
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January 2025
Department of Otolaryngology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China. Electronic address:
The pathophysiological distinctions between osteoarthritis (OA) and diabetic osteoarthritis (DOA) are critical yet not well delineated. In this study, we employed single-cell RNA sequencing to clarify the unique cellular and molecular mechanisms underpinning the progression of both conditions. We identified a novel subpopulation of chondrocytes in DOA, termed 'Heat Shock' chondrocytes, marked by the expression of distinct molecular markers including HSPA1A, HSPA1B, HSPB1, and HSPA8.
View Article and Find Full Text PDFTrop Anim Health Prod
January 2025
School of Molecular Diagnostics, Prophylaxis, and Nanobiotechnology, ICAR- Indian Institute of Agricultural Biotechnology, Garkhtanga, Ranchi, 834003, Jharkhand, India.
Climate change poses significant challenges to livestock production worldwide. Wherein, it affects communities in developing nations primarily dependent on agriculture and animal husbandry. Its direct and indirect deleterious effects on agriculture and animal husbandry includes aberrant changes in weather patterns resulting in disturbed homeorhetic mechanism of livestock vis a vis indirectly affecting nutrient composition of feed and fodder.
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