AI Article Synopsis
- Acute myocardial infarction (AMI) affects young adults differently than older adults, and the mechanisms behind this are not well understood.
- The study measured plasma fatty acid levels in young AMI patients using advanced metabolomic techniques, finding significant changes in fatty acid profiles compared to control and older AMI patients.
- Results indicated that specific fatty acid alterations, particularly a decrease in short-chain fatty acids and an increase in long-chain fatty acids, could serve as potential diagnostic indicators for AMI in young adults.
Article Abstract
Background And Aims: Acute myocardial infarction (AMI) in young adults has distinct clinical features and risk profile as compared with that in elder adults. The pathophysiologic mechanism of AMI in young adults remains unclear. In this study, we used targeted metabolomics to measure metabolic profile and analyzed plasma fatty acids levels in young adults with AMI, seeking to determine whether circulating fatty acid metabolism was correlated with the occurrence of AMI in young adults.
Methods And Results: Consecutive young and elder patients admitted to hospital for AMI were enrolled. Plasma samples of all participants were obtained after overnight fast and then measured using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) based targeted metabolomic platform. A total of 201 plasma metabolites were measured using UPLC-MS/MS. Several plasma fatty acids were significantly altered in young AMI patients compared with control or elder AMI patients, which also showed significant prediction value for AMI in young adults. Percentage of short chain fatty acids (SCFAs) was decreased and long chain increased in AMI as compared with control. Moreover, alpha-linolenic acid and linoleic acid metabolism (ALALAM) pathway metabolites were gradually increased in control, young, and elder AMI patients. Altered fatty acid correlation network further identified fatty acid metabolism disorder in AMI in young adults.
Conclusion: By utilizing targeted metabolomic technique, we have found several altered fatty acids and respective pathways that show diagnostic value for AMI in young adults. SCFA and long-chain fatty acid (LCFA) were differentially altered in AMI patients.
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| http://dx.doi.org/10.1016/j.numecd.2021.06.024 | DOI Listing |
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