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Centenary of Insulin Discovery (1921-2021): Nicolae Paulescu's Original Contributions.
Acta Endocrinol (Buchar)
January 2021
Sanador Clinical Hospital, Department of Neurosurgery, Bucharest, Romania.
Nicolae Paulescu (1869-1930) was born in Bucharest in an aristocratic family. His education from childhood to maturity (Paris University of Medicine) was marked by illustrious professors, even pioneers of their field. After completing his medical and scientific education in Paris under his mentor, Etienne Lancereaux, considered the founder of modern physiology, he returned to Romania where he founded the first Department of Physiology at "Carol Davila" University of Medicine and Pharmacy.
View Article and Find Full Text PDF1921-2021, from insulin to new hypoglycaemic drugs: 100 years of pharmacological research in diabetes mellitus.
Therapie
February 2022
Service de pharmacologie médicale et clinique, centre de pharmacovigilance, pharmacoépidémiologie et d'informations sur le médicament, faculté de médecine, centre hospitalier universitaire, 37, allées Jules-Guesde, 31000 Toulouse, France. Electronic address:
1921-2021: From insulin discovery to islet transplantation in type 1 diabetes.
Ann Endocrinol (Paris)
April 2021
INSERM U1190, 59000 Lille, France; University of Lille, 59000 Lille, France; CHU Lille, Endocrinology, Diabetology, Metabolism, and Nutrition, 59000 Lille, France. Electronic address:
One century after the discovery of insulin, the French Health regulations have just authorized the reimbursement for islet transplantation. Intraportal islet allotransplantation from a pancreatic donor is indicated in patients with type 1 diabetes (T1D) complicated with lability or hypoglycemia unawareness, or in case of a functioning kidney graft; islet auto-transplantation may be indicated after pancreatic surgery.Compared with insulin even administered in closed-loop pumps, the specificity of islet allotransplantation is the restoration of C-peptide secretion.
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