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| http://dx.doi.org/10.1016/j.chest.2021.06.070 | DOI Listing |
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A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials.
JDR Clin Trans Res
December 2024
Department of Biomedical Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Introduction: Evaluating the antiviral potential of commercially available mouthrinses on SARS-CoV-2 holds potential for reducing transmission, particularly as novel variants emerge. Because SARS-CoV-2 is transmitted primarily through salivary and respiratory secretions and aerosols, strategies to reduce salivary viral burden in an antigen-agnostic manner are attractive for mitigating spread in dental, otolaryngology, and orofacial surgery clinics where patients may need to unmask.
Methods: Patients ( = 128) with confirmed COVID-19-positive status within 10 days of symptom onset or positive test result were enrolled in a double-blind randomized controlled trial of Food and Drug Administration-approved mouthrinses containing active ingredients ethanol, hydrogen peroxide, povidone iodine, chlorhexidine gluconate, cetylpyridinium chloride (CPC), or saline.
Effectiveness of Preprocedural Mouthwashes: A Triple-Blind Randomised Controlled Clinical Trial.
Int Dent J
October 2024
Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region, PR China. Electronic address:
Objectives: Bioaerosols generated during dental treatment are considered to be potentially carriers of infectious respiratory pathogens. The use of preprocedural mouthwashes has been suggested to reduce microbial load prior to dental surgery procedures. However, limited evidence on the effectiveness of preprocedural mouthwashes regarding mitigating respiratory pathogens exists.
View Article and Find Full Text PDFImpact of COVID-19 on the Diagnosis of Coarctation of the Aorta in Infants.
Pediatr Cardiol
September 2024
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
Newborns with coarctation of the aorta are a potentially vulnerable population whose diagnosis could have been impacted by the COVID-19 pandemic. The objectives of this study were to assess if there was delayed diagnosis of infants with coarctation and if they had higher acuity prior to repair after the start of the pandemic. The Pediatric Health Information Systems database was queried for patients less than three months of age who underwent surgical repair or palliation of coarctation of the aorta.
View Article and Find Full Text PDFPrevalence of SARS-CoV-2 in Children Identified by Preprocedural Testing at 5 US Children's Hospital Systems.
Pediatr Infect Dis J
January 2025
From the Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Background: The burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic children was initially presumed to be high, which influenced hospital, school and childcare policies. Before vaccines were widely available, some hospitals implemented universal preprocedural SARS-CoV-2 polymerase chain reaction testing on asymptomatic patients. Understanding SARS-CoV-2 prevalence in asymptomatic children is needed to illuminate the diversity of viral characteristics and inform policies implemented during future pandemics.
View Article and Find Full Text PDFThe Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study.
Psychopharmacol Bull
August 2024
Lin, MD, University of Texas Health Sciences Center at Houston, McGovern Medical School, Department of Physical Medicine and Rehabilitation, Houston, TX, USA.
Article Synopsis
- A pilot study was conducted to assess the safety and effectiveness of stellate ganglion blocks for treating long COVID symptoms in 17 patients.
- Before and after the procedure, patients completed surveys measuring various symptoms, revealing that 94% experienced moderate-to-severe autonomic dysfunction prior to treatment, but all reported symptom improvement post-procedure.
- Results indicated significant reductions in fatigue and heart rate, while changes in anxiety and PTSD scores were not statistically significant, suggesting that stellate ganglion blocks could be a useful adjunctive therapy for some long COVID patients.
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