Increasingly complex automated driving functions, specifically those associated with free space detection (FSD), are delegated to convolutional neural networks (CNNs). If the dataset used to train the network lacks diversity, modality, or sufficient quantities, the driver policy that controls the vehicle may induce safety risks. Although most autonomous ground vehicles (AGVs) perform well in structured surroundings, the need for human intervention significantly rises when presented with unstructured niche environments. To this end, we developed an AGV for seamless indoor and outdoor navigation to collect realistic multimodal data streams. We demonstrate one application of the AGV when applied to a self-evolving FSD framework that leverages online active machine-learning (ML) paradigms and sensor data fusion. In essence, the self-evolving AGV queries image data against a reliable data stream, ultrasound, before fusing the sensor data to improve robustness. We compare the proposed framework to one of the most prominent free space segmentation methods, DeepLabV3+ [1]. DeepLabV3+ [1] is a state-of-the-art semantic segmentation model composed of a CNN and an autodecoder. In consonance with the results, the proposed framework outperforms DeepLabV3+ [1]. The performance of the proposed framework is attributed to its ability to self-learn free space. This combination of online and active ML removes the need for large datasets typically required by a CNN. Moreover, this technique provides case-specific free space classifications based on the information gathered from the scenario at hand.
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Sci Rep
January 2025
Zhongyuan University of Technology, Zhengzhou, 450007, China.
This paper studies the practical prescribed-time control problem for dual-arm robots handling an object with output constraints. Firstly, by utilizing the property that the sum of internal forces in the grasping space is zero, the system model is obtained and decomposed into the contact force model and free motion model, which are orthogonal to each other. Furthermore, by combining the performance function and constraint function, the original system tracking error is transformed to a new one, whose boundedness can ensure that the original system variable converges to the predetermined range within the specified time.
View Article and Find Full Text PDFBiotechnol Adv
January 2025
Division of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea; Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea. Electronic address:
Microbial cell factories provide sustainable alternatives to petroleum-based chemical production using cost-effective substrates. A deep understanding of their metabolism is essential to harness their potential along with continuous efforts to improve productivity and yield. However, the construction and evaluation of numerous genetic variants are time-consuming and labor-intensive.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
View Article and Find Full Text PDFUltrasonics
January 2025
The Center for Fast Ultrasound Imaging, Department of Health Technology. Technical University of Denmark, Ørsteds Plads Building 349, Lyngby, DK-2800, Denmark.
Non-invasive estimation of pressure differences using 2D synthetic aperture ultrasound imaging offers a precise, low-cost, and risk-free diagnostic tool. Unlike invasive techniques, this preserves natural blood flow and avoids the limitations of devices that occupy lumen space. This paper evaluates a previously published estimator, modified to incorporate Singular Value Decomposition (SVD) echo-cancellation, using data from ten healthy volunteers and one patient.
View Article and Find Full Text PDFBiophys Chem
January 2025
Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata 700106, India. Electronic address:
Quantitative characterization of protein conformational landscapes is a computationally challenging task due to their high dimensionality and inherent complexity. In this study, we systematically benchmark several widely used dimensionality reduction and clustering methods to analyze the conformational states of the Trp-Cage mini-protein, a model system with well-documented folding dynamics. Dimensionality reduction techniques, including Principal Component Analysis (PCA), Time-lagged Independent Component Analysis (TICA), and Variational Autoencoders (VAE), were employed to project the high-dimensional free energy landscape onto 2D spaces for visualization.
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