Key Messages: Visual acuity is the most used method to assess visual function in children. Contrast sensitivity complements the information provided for visual acuity, but it is not commonly used in clinical practice. Digital devices are increasingly used as a method to evaluate visual function, due to multiple advantages. Testing with these devices can improve the evaluation of visual development in children from a few months of age. Visual acuity and contrast sensitivity tests, using eye tracking technology, are able to measure visual function in children across a wide range of ages, objectively, quickly and without need of an experienced examiner.
Purpose: To report age-normative values for grating visual acuity and contrast sensitivity in healthy children using a digital device with eye tracking technology and to validate the grating acuity test.
Methods: In the first project of the study, we examined healthy children aged between 6 months and 7 years with normal ophthalmological assessment. Grating visual acuity (VA) and contrast sensitivity (CS) were assessed using a preferential gaze paradigm with a DIVE (Device for an Integral Visual Examination) assisted with eye tracking technology to provide age norms. For the validation project, we compared LEA grating test (LGT) with DIVE VA in a group of children aged between 6 months and 4 years with normal and abnormal visual development.
Results: Fifty-seven children (2.86 ± 1.55 years) were examined with DIVE VA test and 44 successfully completed DIVE CS test (3.06 ± 1.41 years). Both, VA and CS values increased with age, mainly along the first two years of life. Sixty-nine patients (1.34 ± 0.61 years) were included in the DIVE VA test validation. The mean difference between LGT and DIVE VA was - 1.05 ± 4.54 cpd with 95% limits of agreement (LoA) of - 9.95-7.84 cpd. Agreement between the two tests was higher in children younger than 1 year with a mean difference of - 0.19 ± 4.02 cpd.
Conclusions: DIVE is an automatic, objective and reliable tool to assess several visual function parameters in children, and it has good agreement with classical VA tests, especially for the first stage of life.
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http://dx.doi.org/10.1007/s10792-021-02040-4 | DOI Listing |
Front Immunol
January 2025
Department of Hematology and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Immune dysfunction is one of the hallmarks of cancer and plays critical roles in immunotherapy resistance, but there is no serum biomarker that can be used to evaluate immune-dysfunction status of cancer patients. Here, we identified subtype-specific human endogenous retrovirus K102 envelope (HERV-K102-Env) with immunosuppressive activity in circulating blood as a novel serum immunosuppressive biomarker of cancer. We first generated monoclonal antibodies against K102-Env with high sensitivity and specificity, and we developed an ELISA assay to detect serum K102-Env.
View Article and Find Full Text PDFFront Neurosci
January 2025
School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Purpose: Astigmatism can lead to meridional amblyopia, an orientation-specific visual deficit. This study investigated the effects of astigmatism on meridional anisotropy in contrast sensitivity (CS) and steady-state visual evoked potential (ssVEP) across a range of spatial frequencies.
Methods: Thirty-two young adults with a best-corrected distance visual acuity of logMAR 0 or better were categorized into two groups: highly astigmatic (HAS, = 16) with spherical-equivalent error (SE) ≥ -6.
Brain Spine
December 2024
Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands.
Research Question: The goal of this study was to assess the diagnostic accuracy of spinal time-resolved contrast-enhanced MR angiography (4D-MRA) for the detection and localization of spinal dural arteriovenous fistulas (SDAVF) in our institution.
Material And Methods: Single center retrospective cohort study of patients with the clinical suspicion of a SDAVF. Patients were included who had undergone spinal 4D-MRA in the period January 2010-February 2021.
Heliyon
January 2025
Department of Energy System Engineering, Faculty of Mechanical Engineering, K.N. Toosi University of Technology, No. 15, Pardis St., Molasadra Ave., Vanak Sq., Tehran, Iran.
The rising global demand for air conditioning systems, driven by increasing temperatures and urbanization, has led to higher energy consumption and greenhouse gas emissions. HVAC systems, particularly AC, account for nearly half of building energy use, highlighting the need for efficient cooling solutions. Passive cooling, especially radiative cooling, offers potential to reduce cooling loads and improve energy efficiency.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Ultrasonography, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Background: Accurate identification of small metastatic lymph nodes (LNs) remains a significant challenge with conventional ultrasound (US) due to its limitations in sensitivity for smaller LNs. The use of contrast-enhanced ultrasound (CEUS), especially with perfluorobutane in the postvascular phase of CEUS, may improve the diagnosis of metastatic LNs in cancer patients. We sought to investigate the diagnostic accuracy of the postvascular phase of CEUS with perfluorobutane in identifying suspected small cervical LNs in cancer patients.
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