B cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8 T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF. NK cell migration into BCF in chronically SIVagm-infected AGM is associated with CXCR5 NK cells. We aimed to identify the mechanism leading to CXCR5 expression on NK cells. We show that CXCR5 NK cells in LN were induced following SIVagm infection. CXCR5 NK cells accumulated preferentially in BCF with proliferating B cells. Autologous NK-B cell co-cultures in transwell chambers induced CXCR5 NK cells. Transcriptome analysis of CXCR5 NK cells revealed expression of and . IL-6 induced CXCR5 on AGM and human NK cells. mRNA was detected in LN at higher levels during SIVagm than SIVmac infection and often produced by plasma cells. Our study reveals a mechanism of B cell-dependent NK cell regulation.
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| http://dx.doi.org/10.1016/j.isci.2021.103109 | DOI Listing |
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