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MYOPERICARDITIS DUE TO COXIELLA BURNETII IN A TEENAGE MALE.

Pediatr Infect Dis J

November 2024

From the Division of Pediatric Infectious Diseases and Global Health, Department of Pediatrics, University of California San Francisco, San Francisco, San Francisco, California.

A 15-year-old male presented with acute chest pain and was diagnosed with myopericarditis due to acute Q fever, detected by cell-free DNA method. Despite taking a 2-week course of doxycycline, myopericarditis recurred after 6 months. In the absence of an alternative diagnosis, he began treatment for possible chronic Q fever with doxycycline and hydroxychloroquine and has not had further recurrence.

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The incidence of myocarditis and pericarditis has been documented in adolescents after COVID-19 vaccinations. This study aims to assess the risk of myopericarditis in adolescents following COVID-19 vaccination, using a meta-analysis of the published cases. We performed a comprehensive literature search of the following databases on July 5, 2023: MEDLINE, EMBASE, PubMed, and the Cochrane Library.

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Article Synopsis
  • The study focuses on pediatric patients who experienced cardiac adverse events following COVID-19 vaccination with Pfizer/BioNTech, specifically looking at cases from May 2021 to May 2022.
  • Out of 17 male adolescents (average age 16), most cases of myopericarditis occurred after the 2nd or 3rd vaccine dose, with all patients showing improvement on anti-inflammatory medications.
  • While all patients recovered, some reported negative impacts on their quality of life and developed vaccine hesitancy, emphasizing the need for effective follow-up and support for individuals who experience vaccine-related side effects.
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Characterization of Brighton Collaboration criteria for myocarditis and pericarditis following COVID-19 vaccine in Korean adolescents.

Vaccine

May 2024

Department of Pediatrics, Korea University Anam Hospital, Seoul, Republic of Korea; Department of Pediatrics, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address:

Article Synopsis
  • Vaccines are essential for public health, yet there are ongoing concerns about potential side effects like myocarditis and pericarditis linked to COVID-19 vaccines, which this study aims to investigate using national safety data.
  • The research examined 190 medical records of individuals who claimed to have developed myo/pericarditis after vaccination, categorizing the cases based on the Brighton Collaboration criteria.
  • The findings revealed that the majority of cases (70%) were classified as Level 2, with higher hospitalization rates in Level 1 cases, providing insights into the potential effects of the COVID-19 vaccine on heart health.
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Fibrosing mediastinitis (FM) is a rare, potentially progressive disease resulting from an idiosyncratic immune response to a variety of stimuli that lead to fibrous infiltration of the mediastinum and possible narrowing of the bronchovascular structures. We report an unusual case of FM in a pediatric patient presenting as myopericarditis and progressing to pericardial thickening and encasement of the mediastinal vascular structures needing surgical intervention. Imaging, including transthoracic echocardiography, cardiac computed tomography, and cardiac magnetic resonance played a crucial role in the diagnosis, assessment, and follow-up.

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