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| http://dx.doi.org/10.1016/j.ekir.2021.07.014 | DOI Listing |
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Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals.
Sci Rep
January 2025
NMC Genetics India Pvt. Ltd., Gurugram, Haryana, 122001, India.
Rising cases of type 2 diabetes (T2D) in India, especially in metropolitan cities is an increasing concern. The individuals that were most affected are young professionals working in the corporate sector. However, the corporate sector has remained the least explored for T2D risk predisposition.
View Article and Find Full Text PDFProteomics for Biomarker Discovery in Gynecological Cancers: A Systematic Review.
J Proteome Res
January 2025
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
The present study aims to summarize the current biomarker landscape in gynecological cancers (GCs) and incorporate bioinformatics analysis to highlight specific biological processes. The literature was retrieved from PubMed, Web of Science, Embase, Scopus, Ovid Medline, and Cochrane Library. The final search was conducted on December 7, 2022.
View Article and Find Full Text PDFConjoint analysis of methylation, transcriptomic, and proteomic profiles in pemphigus vulgaris.
Orphanet J Rare Dis
November 2024
Department of Dermatology, Haikou Branch hospital of the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650014, China.
Background: The underlying pathogenesis of pemphigus vulgaris, an autoimmune skin disorder, remains incompletely understood. An integrative analysis comprising DNA methylation, mRNA expression, and proteomic data in patients with pemphigus vulgaris was conducted to identify potential pathogenic contributors and explore the molecular mechanisms involved in its pathogenesis.
Results: The analysis revealed differentially methylated regions (DMRs) in the promoter, exon, intron, and downstream regions in the peripheral blood DNA of patients with pemphigus vulgaris.
Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and nanoscale liquid chromatography-tandem mass spectrometry.
J Vet Intern Med
December 2024
Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Background: Chronic gingivostomatitis in cats (FCGS) is a moderately to severely painful condition, potentially caused by inadequate immune response to oral antigenic stimulation. Salivary peptidome analysis can identify inflammatory protein mediators and pathways involved in oral mucosal immune activation and may indicate potential therapeutic options for FCGS.
Objective: Evaluate the diversity and abundance of salivary peptides in cats with FCGS using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and nanoscale liquid chromatography-tandem mass spectrometry (nano LC-MS/MS).
Astral-DIA proteomics: Identification of differential proteins in sheep, goat, and cow milk.
Int J Biol Macromol
December 2024
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China. Electronic address:
Dairy products are of great benefit to human health, and the nutritional differences between different dairy products have attracted attention. In this study, DIA proteomics technique, combined with parallel reaction monitoring (PRM) as a validation method, was used for the qualitative and quantitative analysis of proteins in sheep, goat, and cow milk. In total, 4316 proteins were identified.
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