Purpose: To compare Netra smartphone-based and automated refraction with subjective refraction for screening of refractive errors.
Methods: Cross-sectional study at the University of Malaya Medical Centre, Kuala Lumpur. Subjects underwent subjective refraction, then automated refraction, and finally Netra smartphone-based refraction. All results were converted to power vectors (M, J0 and J45) and were analysed using repeated-measures ANOVA and Bland-Altman plots. Sensitivity and specificity were determined. The best cut-off points were determined from ROC curve analysis. < .05 was considered statistically significant.
Results: Data from the right eyes of 204 subjects were analysed. Mean age was 36.6 ± 15.7 years (range 16-78 years). Spherical equivalent [mean (95% CI)] from Netra and automated refraction were similar, and both more myopic than subjective refraction; -2.87 (-3.23 to -2.51), -2.85 (-3.21 to -2.49) and -2.46 (-2.83 to -2.10) respectively ( < .001). Differences in J0 and J45 between Netra and subjective refraction were not statistically significant (0.10 vs 0.11 and 0.01 vs -0.02 respectively, both > .05), but those between automated and subjective refraction were (0.06 vs 0.11 and 0.07 vs -0.02, = .004 and < .001 respectively). Bland Altman plots showed the 95% limits of agreement with Netra refraction were wider than with automated refraction (-2.21D to 1.42D vs. -1.90D to 1.16D respectively).
Conclusion: Netra smartphone-based refraction gives similar readings to automated refraction, and both show myopic overestimation when compared to subjective refraction. However, due to non-insignificant practical usage issues, its use as a screening tool for refractive errors is limited.
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http://dx.doi.org/10.1080/09286586.2021.1986550 | DOI Listing |
Biomed Opt Express
January 2025
Department of Electronic Engineering, Maynooth University, Maynooth, Co. Kildare, Ireland.
Optical diffraction tomography enables label-free, 3D refractive index (RI) imaging of biological samples. We present a novel, cost-effective approach to ODT that employs a modular design incorporating a self-reference holographic capture module. This two-part system consists of an illumination module and a capture module that can be seamlessly integrated with any life-science microscope using an automated alignment protocol.
View Article and Find Full Text PDFOphthalmol Sci
November 2024
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Purpose: The diagnosis of fungal keratitis using potassium hydroxide (KOH) smears of corneal scrapings enables initiation of the correct antimicrobial therapy at the point-of-care but requires time-consuming manual examination and expertise. This study evaluates the efficacy of a deep learning framework, dual stream multiple instance learning (DSMIL), in automating the analysis of whole slide imaging (WSI) of KOH smears for rapid and accurate detection of fungal infections.
Design: Retrospective observational study.
Optom Vis Sci
January 2025
Johnson & Johnson MedTech (Vision), Irvine, California.
Significance: Optimal meibography utilization and interpretation are hindered due to poor lid presentation, blurry images, or image artifacts and the challenges of applying clinical grading scales. These results, using the largest image dataset analyzed to date, demonstrate development of algorithms that provide standardized, real-time inference that addresses all of these limitations.
Purpose: This study aimed to develop and validate an algorithmic pipeline to automate and standardize meibomian gland absence assessment and interpretation.
Adv Mater
January 2025
National Key Laboratory of Microwave Photonics, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
As one of the typical applications of metamaterials, the invisibility cloak has raised vast research interests. After many years' research efforts, the invisibility cloak has extended its applicability from optics and acoustics to electrostatics and thermal diffusion. One scientific challenge that has significantly restricted the practical application of the invisibility cloak is the strong background dependence, that is, all passive cloaking devices realized thus far are unable to resist variation in the background refractive index.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Institute for Applied Mathematics, University of Bonn, Bonn, Germany.
Purpose: To quantify outer retina structural changes and define novel biomarkers of inherited retinal degeneration associated with biallelic mutations in RPE65 (RPE65-IRD) in patients before and after subretinal gene augmentation therapy with voretigene neparvovec (Luxturna).
Methods: Application of advanced deep learning for automated retinal layer segmentation, specifically tailored for RPE65-IRD. Quantification of five novel biomarkers for the ellipsoid zone (EZ): thickness, granularity, reflectivity, and intensity.
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