A newly identified regulator increases the efficacy of a new class of targeted anti-RAS drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680106 | PMC |
| http://dx.doi.org/10.1126/science.abl3639 | DOI Listing |
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Filling data analysis gaps in time-resolved crystallography by machine learning.
Struct Dyn
January 2025
Department of Physics, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, Wisconsin 53211, USA.
There is a growing understanding of the structural dynamics of biological molecules fueled by x-ray crystallography experiments. Time-resolved serial femtosecond crystallography (TR-SFX) with x-ray Free Electron Lasers allows the measurement of ultrafast structural changes in proteins. Nevertheless, this technique comes with some limitations.
View Article and Find Full Text PDFUnmet clinical needs in women with polycystic ovary syndrome regarding fertility and obesity: a cross-sectional study from the patient's perspective.
Arch Gynecol Obstet
January 2025
Division of Gynaecological Endocrinology and Reproductive Medicine, University Hospital Inselspital, Bern, Switzerland.
Purpose: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often leading to anovulatory infertility. Obesity exacerbates the reproductive, metabolic and psychological features of PCOS, making fertility treatment and patient satisfaction difficult. Despite guidelines from the European Society of Human Reproduction and Embryology (ESHRE) emphasizing lifestyle modifications and specific treatments, there remains a significant gap in adherence to these guidelines by both healthcare providers and patients.
View Article and Find Full Text PDFMechanical Properties and Optimization Strategies of Tree Fork Structures.
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January 2025
Department of Horticulture, National Chung Hsing University, Taichung City 40227, Taiwan.
Trees are complex and dynamic living structures, where structural stability is essential for survival and for public safety in urban environments. Tree forks, as structural junctions, are key to tree integrity but are prone to failure under stress. The specific mechanical contributions of their internal conical structures remain largely unexplored.
View Article and Find Full Text PDFInteractions between environmental pollutants and gut microbiota: a review connecting the conventional heavy metals and the emerging microplastics.
Environ Res
January 2025
Department of Civil and Environmental Engineering, National University of Kaohsiung, Kaohsiung 81148, Taiwan, R.O.C. Electronic address:
Growing epidemiological evidence suggests that the diverse and functional gut microbiota plays a vital role in regulating the health and disease of organisms including human. However, organisms are inevitably exposed to widespread environmental pollutants, and the interactions between their gut microbiota and pollutants are relatively underreported. The present paper considers heavy metals (HMs) and microplastics (MPs) as representatives of traditional and emerging pollutants and systematically summarizes their effects on gut microbiota and the effects of gut microbiota on pollutants.
View Article and Find Full Text PDFChildhood executive control and adolescent substance use: Mediation via parent-child relationship quality.
Fam Relat
December 2024
Department of Youth and Family Studies, Center for Research on Children, Youth, Families, and Schools, University of Nebraska-Lincoln.
Objective: The goal of the current study was to test prospective direct and indirect associations between preschool executive control (EC), parental affective quality and harsh discipline, and adolescent substance use (e-cigarettes, cannabis, and alcohol) while accounting for participants' age, sex, family history of substance use, and family socioeconomic status.
Method: Participants were 313 youth (49% boys; 70.9% European American) and their parents who participated in a longitudinal cohort-sequential study on the development of EC in preschool and its associations with subsequent health outcomes.
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