Bischler-Napieralski Synthesis of 6-Alkynyl Phenanthridines Based on TfO-Promoted Electrophilic Activation of -Aryl-2-propynamides.

J Org Chem

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China.

Published: November 2021

An efficient method for the synthesis of 6-alkynyl phenanthridines was developed. The method offered the first example to use 2-propynamides as substrates in the Bischler-Napieralski reaction and to create alkynylnitrilium triflates as new active intermediates in organic synthesis.

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Source
http://dx.doi.org/10.1021/acs.joc.1c01543DOI Listing

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