Cancer-associated keratinocytes: new members of the microenvironment in head and neck cancer.

Mol Cell Oncol

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Published: July 2021

The tumor microenvironment is a complex ecosystem of malignant and nonmalignant cells and extracellular proteins that work together to enhance tumor progression. We identified a mechanism in which adjacent nonmalignant epithelium enhances invasion of squamous cell carcinoma, thereby expanding the tumor microenvironment to include cancer-associated keratinocytes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489914PMC
http://dx.doi.org/10.1080/23723556.2021.1933329DOI Listing

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