Background: Previous studies demonstrated impaired auditory processing in children with sagittal and metopic craniosynostosis before surgical correction. This study investigated whether worse presurgical neural response as assessed by event-related potentials (ERP) was predictive of poorer school-age neurocognition.
Methods: Preoperative infant ERP was recorded in 15 sagittal and 18 metopic patients. Mismatch negativity and P150 paradigms were derived from ERP recordings, as previously published. Of those, 13 sagittal and 13 metopic patients returned for neurocognitive evaluation 6 or more years later. ERP was correlated to neurocognitive outcomes using Spearman's correlations controlling for age. Two-tailed t-tests were used to evaluate the influence of age at the time of surgery (6 months) and morphologic severity on neurocognitive outcomes.
Results: In the sagittal group, no significant correlations were found between preoperative mismatch negativity or P150 amplitudes and neurocognitive outcomes. Although no correlation was found between mismatch negativity and neurocognitive outcome in the metopic group, those with lower P150 amplitudes had higher scores in performance IQ (r = -0.877, P < 0.001) and full-scale IQ (r = -0.893, < 0.001). Morphologic severity and neurocognitive outcomes showed no relationship in the sagittal or metopic groups. Patients who received surgery at less than 6 months had higher full-scale IQ (109.69 versus 95.92, = 0.025), visuomotor integration (103.15 versus 90.46, = 0.041), and visual perception scores (105.69 versus 96.08, = 0.033).
Conclusions: Preoperative infant ERP does not correlate with school-age neurocognitive outcomes. Earlier age at the time of surgery was associated with improved neurocognitive outcomes.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489894 | PMC |
http://dx.doi.org/10.1097/GOX.0000000000003844 | DOI Listing |
Alzheimers Dement
December 2024
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.
Introduction: Poor cardiovascular health (CVH) is linked to Alzheimer's disease and dementia; however, its association with neurocognitive trajectories earlier in life remains underexplored.
Methods: We included 3224 participants with information on CVH at early midlife (mean age 45.0 ± standard deviation 3.
J Cardiothorac Surg
December 2024
Nanjing Medical University, Longmian Avenue No.101, Jiangning District, Nanjing, Jiangsu, China.
Background: Postoperative delirium (POD) is a cognitive decline and attention deficit that can occur in patients after cardiac surgery. Despite extensive research identifying the risk factors, POD often remains undiagnosed and untreated in medical settings. Therefore, this systematic literature review (SLR) aimed to summarize the available studies on early POD identification in patients following cardiovascular surgery.
View Article and Find Full Text PDFHum Brain Mapp
December 2024
Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
The human hippocampus is a key region in cognitive and emotional processing, but also a vulnerable and plastic region. Accordingly, there is a great interest in understanding how variability in the hippocampus' structure relates to variability in behavior in healthy and clinical populations. In this study, we aimed to link interindividual variability in subregional hippocampal networks (i.
View Article and Find Full Text PDFCNS Neurosci Ther
December 2024
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Non-invasive brain stimulation (NIBS), such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), has emerged as a promising alternative in the precise treatment of clinical symptoms, such as the cognitive impairment of bipolar disorder (BD). Optimizing the neurocognitive effects by combining tDCS and rTMS to strengthen the clinical outcome is a challenging research issue.
Objective: In this randomized, controlled trial, we first combined tDCS and neuronavigated rTMS targeting the V1 region to explore the efficacy on neurocognitive function in BD patients with depressive episodes.
Cogn Affect Behav Neurosci
December 2024
Department of Psychology, University of Chicago, Chicago, IL, 60637, USA.
The extent to which a belief is rooted in one's sense of morality has significant societal implications. While moral conviction can inspire positive collective action, it can also prompt dogmatism, intolerance, and societal divisions. Research in social psychology has documented the functional characteristics of moral conviction and shows that poor metacognition exacerbates its negative outcomes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!