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A spatiotemporal and machine-learning platform facilitates the manufacturing of hPSC-derived esophageal mucosa.
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January 2025
Program in Epithelial Biology and Center for Definitive and Curative Medicine, Stanford University, Stanford, CA, USA. Electronic address:
Human pluripotent stem cell-derived tissue engineering offers great promise for designer cell-based personalized therapeutics, but harnessing such potential requires a deeper understanding of tissue-level interactions. We previously developed a cell replacement manufacturing method for ectoderm-derived skin epithelium. However, it remains challenging to manufacture the endoderm-derived esophageal epithelium despite possessing a similar stratified epithelial structure.
View Article and Find Full Text PDFA single-nuclei transcriptome census of the Arabidopsis maturing root identifies that MYB67 controls phellem cell maturation.
Dev Cell
January 2025
Plant Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:
The periderm provides a protective barrier in many seed plant species. The development of the suberized phellem, which forms the outermost layer of this important tissue, has become a trait of interest for enhancing both plant resilience to stresses and plant-mediated CO sequestration in soils. Despite its importance, very few genes driving phellem development are known.
View Article and Find Full Text PDFProximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage.
Biomedicines
December 2024
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Background/objectives: The enzyme ubiquitin-specific protease 44 (USP44) is a deubiquitinating enzyme with identified physiological roles as a tumor suppressor and an oncogene. While some binding partners and substrates are known for USP44, the identification of other interactions may improve our understanding of its role in cancer. We therefore performed a proximity biotinylation study that identified products of several known cancer genes that are associated with USP44, including a novel interaction between BRCA2 and USP44.
View Article and Find Full Text PDFQuantifying spatial inequities in traffic injury rates through the integration of urban road network measures and social vulnerability.
Accid Anal Prev
March 2025
School of System Science, Beijing Jiaotong University, Beijing 100044 PR China. Electronic address:
Mitigating traffic injury rate plays an essential role in sustainable urban development and is closely related to public health and human well-being. The inequity of traffic injury rate undermines equitable access to transportation infrastructure and poses a significant threat to the safety of residents during their commutes. Although previous studies have examined the association between socio-demographic characteristics and regional traffic crash risk, they seldom consider the spatial heterogeneity of the traffic injury rate inequity especially for the vulnerable groups.
View Article and Find Full Text PDFTranscriptomic DN3 clock neuron subtypes regulate sleep.
Sci Adv
January 2025
Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.
Article Synopsis
- Researchers used single-cell RNA sequencing to examine clock neurons in animal brains, particularly focusing on the DN3s, which are a major type of clock neuron in fruit flies.
- DN3s were found to be organized into 12 unique clusters with distinct gene expression patterns that set them apart from other clock neurons.
- The study revealed that certain DN3 subtypes play a significant role in promoting sleep through a specific receptor, suggesting a complex relationship between clock neurons and sleep regulation.
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