We evaluated the potential influence of genetic (, , , , , , , and ) and nongenetic factors on carbamazepine (CBZ) response, adverse drug reactions and CBZ plasma concentrations in 126 Mexican Mestizos (MM) with epilepsy. Patients were genotyped for 27 variants using TaqMan assays. CBZ response was associated with variants and lamotrigine cotreatment. CBZ-induced adverse drug reactions were related to antiepileptic polytherapy and rs2298771/rs3812718 haplotype. CBZ plasma concentrations were influenced by -rs2276707 and -rs3814058, and by phenytoin cotreatment. CBZ daily dose was also influenced by -rs3814055 and -rs1051740. Interindividual variability in CBZ treatment was partly explained by , and variants, as well as antiepileptic cotreatment in MM with epilepsy.
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http://dx.doi.org/10.2217/pgs-2021-0081 | DOI Listing |
J Physiol Investig
November 2024
Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.
Tomatidine, a major tomato glycoalkaloid, is effective for the prevention of skeletal muscle wasting and enhancing mitophagy. However, its effects on transmembrane ionic currents are not well explored. In this study, we explored the interactions between tomatidine and Na+ current.
View Article and Find Full Text PDFFront Pharmacol
October 2024
School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Clinical studies have shown that epileptic seizures worsen Alzheimer's disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear. To assess the effects of seizures on the progression of AD, chronic temporal lobe epilepsy was induced in five familial AD mutation (5×FAD) mice by kindling with the chemoconvulsant pentylenetetrazole (PTZ) at 3-3.5 months of age.
View Article and Find Full Text PDFEnviron Res
January 2025
School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an, 710055, China.
Addressing the treatment of complex industrial wastewater continues to be a substantial challenge within the realm of water treatment. A biofilm reactor was engineered, integrating lotus stem biochar, lotus stem biological filler, and the ZW5 strain for enhanced wastewater treatment. The removal efficiencies of nitrate (NO-N), calcium (Ca), chemical oxygen demand (COD), phosphorus (PO-P), plumbum (Pb), and carbamazepine (CBZ) were 98.
View Article and Find Full Text PDFNanomaterials (Basel)
October 2024
Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Ivana Lučića 5, 10002 Zagreb, Croatia.
Batch heterogeneous catalytic ozonation experiments were performed using commercial and synthesized nanoparticles as catalysts in aqueous ozone. The transferred ozone dose (TOD) ranged from 0 to 150 μM, and nanoparticles were added in concentrations between 0 and 1.5 g L, with all experiments conducted at 20 °C and a total volume of 240 mL.
View Article and Find Full Text PDFJ Dermatol Sci
December 2024
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions with extensive keratinocyte death. Carbamazepine (CBZ), the most commonly implicated drug in SJS/TEN, is metabolized by the cytochrome P450 enzyme 3A4 (CYP3A4) into carbamazepine-10,11-epoxide (CBZE) in the liver. While CD8 cytotoxic T cells play an important role in SJS/TEN, the underlying mechanism of exuberant immune response by CD8 T cells in these conditions remains incompletely understood.
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