One nucleotide replacement in codon 177 of HLA-DRB1*07:01:01:01 results in a novel allele, HLA-DRB1*07:130.
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| http://dx.doi.org/10.1111/tan.14442 | DOI Listing |
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Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.
EBioMedicine
October 2023
Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address:
Background: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles are associated with specific HLA genetic variants and clinical manifestations in IIM.
Methods: We included 1348 IIM patients and determined the occurrence of 14 myositis-specific or -associated autoantibodies.
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