AI Article Synopsis
- Malaria is a serious disease treated primarily with oral medications to effectively reduce its impact and spread.
- The World Health Organization recognizes several common antimalarial drugs, including chloroquine and artemether, available in various formulations.
- This review focuses on the advancements in analytical methods, particularly liquid chromatography, used over the past decade to measure these drugs in pharmaceuticals and human blood, including their statistical evaluations.
Article Abstract
Malaria is a life-threatening disease being treated by oral medication. This is the best treatment to reduce morbidity and mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials. According to the World Health Organization, the most common antimalarial drugs are chloroquine, primaquine, mefloquine, lumefantrine, artemether, and artesunate in single dosage forms or fixed-dose combination. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to the determination of these antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography in the last 10 years, along with statistical analyses of the methods.
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| http://dx.doi.org/10.1039/d1ay01173a | DOI Listing |
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