An aerobic metal-free, visible-light-induced regioselective thiolation of phenols with thiophenols is reported. The cross-coupling protocol exhibits great functional group tolerance and high regioselectivity. Mechanistic studies reveal that the disulfide radical cation plays a crucial role in the visible-light catalysis of aerobic thiolation. Simply controlling the equivalent ratio of substrates enables the selective formation of sulfide or sulfoxide products with high activity in a one-pot reaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c03090 | DOI Listing |
Publication Analysis
Top Keywords
visible-light catalysis
8
catalysis aerobic
8
direct c-h
4
c-h thiolation
4
thiolation selective
4
selective cross-coupling
4
cross-coupling arenes
4
arenes thiophenols
4
thiophenols aerobic
4
aerobic visible-light
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!