This paper describes a global monthly gridded Sea Surface Temperature (SST) and Sea Ice Concentration (SIC) dataset for the period 1000-1849, which can be used as boundary conditions for atmospheric model simulations. The reconstruction is based on existing coarse-resolution annual temperature ensemble reconstructions, which are then augmented with intra-annual and sub-grid scale variability. The intra-annual component of HadISST.2.0 and oceanic indices estimated from the reconstructed annual mean are used to develop grid-based linear regressions in a monthly stratified approach. Similarly, we reconstruct SIC using analog resampling of HadISST.2.0 SIC (1941-2000), for both hemispheres. Analogs are pooled in four seasons, comprising of 3-months each. The best analogs are selected based on the correlation between each member of the reconstructed SST and its target. For the period 1780 to 1849, We assimilate historical observations of SST and night-time marine air temperature from the ICOADS dataset into our reconstruction using an offline Ensemble Kalman Filter approach. The resulting dataset is physically consistent with information from models, proxies, and observations.
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http://dx.doi.org/10.1038/s41597-021-01043-1 | DOI Listing |
NPJ Prim Care Respir Med
January 2025
Centre for Tuberculosis Research, Departments of Clinical Sciences and International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK.
Evidence relating to peer support and community-based psychological and social (psychosocial) interventions to reduce stigma and depression among people with tuberculosis (TB) and their households is limited. This study aimed to engage with multisectoral stakeholders in Indonesia to co-develop a peer-led, community-based psychosocial intervention that is replicable, acceptable, and sustainable. We used a participatory action design and engaged key national, multisectoral stakeholders to ensure that the intervention co-design was relevant and appropriate to the TB health system and the sociocultural context of Indonesia.
View Article and Find Full Text PDFLancet Diabetes Endocrinol
January 2025
LIB Therapeutics, Cincinnati, OH, USA. Electronic address:
Background: Lerodalcibep, a small binding anti-PCSK9 protein (adnectin), showed effective LDL cholesterol reduction in heterozygous familial hypercholesterolaemia. We aimed to assess the safety and efficacy of lerodalcibep and evolocumab in a globally diverse homozygous familial hypercholesterolaemia population.
Methods: This phase 3, randomised, open-label, crossover, non-inferiority study consisted of two 24-week treatment periods separated by an 8-week washout.
Geospat Health
January 2025
Faculty of Public Health, Khon Kaen University, Khon Kaen.
Antibiotic Self-Medication (ASM) is a major contributing factor to Antimicrobial Resistance (AMR) that can lead to both mortality and long-term hospitalizations. High provincial ASM proportions associated with mortality due to AMR have been observed in Thailand but there is a lack of studies on geographic factors contributing to ASM. The present study aimed to quantify the distribution of ASM in Thailand and its correlated factors.
View Article and Find Full Text PDFHeliyon
January 2025
Institute of Geo-information and Earth Observation Sciences, Mekelle University, P.O. Box 231, Mekelle, Ethiopia.
of long-term and future climate variability is crucial for impact assessment studies in drought-prone areas like the Giba basin in northern Ethiopia. This study has applied the statistical downscaling model (SDSM) and (De Martonne and Pinna combinative) aridity index methods to evaluate the climate system of the Giba basin. Historical data (1961-2019) from seven meteorological stations and global grided data were used for future climate projections (2020-2100) under the three emission scenarios (RCPs 2.
View Article and Find Full Text PDFJMIR Public Health Surveill
January 2025
Department of Health Services Research and Administration, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States.
Background: Mental illness affects an estimated 25% of the global population, with treatment gaps persisting worldwide. The COVID-19 pandemic has exacerbated these challenges, leading to a significant increase in mental health issues globally. In Saudi Arabia, the lifetime prevalence of mental disorders is estimated at 34.
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