NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating expression.

Epigenomics

Department of Obstetrics & Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.

Published: October 2021

To investigate the role and function of NOL6, a protein related to ribosome biogenesis, in endometrial cancer. Methyl thiazolyl tetrazolium assay, colony formation assay, flow cytometry apoptosis assay, transwell assay and wound healing assays were carried out for evaluating cell proliferation, migration and apoptosis. Immunohistochemistry, western blot and tumor xenograft assays were carried out for detecting the level of protein expression and tumor formation. We demonstrated that NOL6 is overexpressed in endometrial cancer and promotes cell proliferation and migration while reducing apoptosis. NOL6 regulates the expression of , which can restore the changes in cells caused by knockdown. NOL6 can promote the proliferation and migration of endometrial cancer cells by regulating expression.

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http://dx.doi.org/10.2217/epi-2021-0218DOI Listing

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