Two various materials, copper and aluminum doped cobalt ferrite nanoparticles (NPs) were fabricated for investigating their effects of addition amounts on hydrogen (H) synthesis and process stability. CoCuFeONPs enhanced H production more than CoAlFeO NPs under same condition. The highest H yield of 212.25 ml/g glucose was found at optimal dosage of 300 mg/L CoCuFeO NPs, revealing the increases of 43.17% and 6.67% compared with the control without NPs and 300 mg/L CoAlFeO NPs groups, respectively. NPs level of more than 400 mg/L inhibited H generation. Further investigations illustrated that CoCuFeO NPs were mainly distributed on extracellular polymer substance while CoAlFeO NPs were mostly enriched on cell membrane, which facilitated electron transfer behavior. Community structure composition demonstrated that CoCuFeO and CoAlFeO separately caused a 9.67% and 9.03% increase in Clostridium sensu stricto 1 compared with the control reactor without NPs exposure.
Introduction: Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), a widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards a combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined with Chitosan-Au nanoparticles for chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted efficacy and minimizing side effects.
Objective: To explore the possible mechanism of absorption of iron oxide nanoparticles into the human body through the gastrointestinal tract.
Methods: This article used Caco-2 monolayer cells as a cell model, prepared characterized iron oxide nanoparticles(Fe_2O_3 NPs) as suspensions, and intervened in Caco-2 cells. CCK-8 method, transwell method, and atomic spectrophotometer method were used to explore the effect of Fe_2O_3 NPs on the activity of Caco-2 cells and the absorption and transport of them through the Caco-2 monolayer cell model.
The widespread use of plastics in the food industry raises concerns about plastic migration and health risks. The degradation of primary polymers like polystyrene (PS) and polyethylene (PE) can generate nanoplastics (NPs), increasing food biohazard. This study assessed the impact of PS, PE, and PS + PE NPs on (CV) and (HP) before and after in vitro and ex vivo digestion, focusing on particle size, polydispersity index, and surface charge.
The level of serum bilirubin is associated with the incidence of lung cancer in both smokers and non-smokers, but the specific mechanism is unknown. Bilirubin nanoparticles (BRNPs) were synthesized to explore the effects on Treg/Th17 immunity and gut microbiota in Lewis Lung Carcinoma (LLC) mice, to provide insights for the treatment of lung adenocarcinoma. 10 μg/mL BRNPs promoted apoptosis of A549, NCI-H1299 and LLC cells.
Nanoparticles have been of significant interest in various biomedical domains such as drug delivery, gene delivery, cytotoxicity analysis, and imaging. Despite the synthesis of a variety of nanoparticles, their cellular uptake efficiency remains a substantial obstacle, with only a small fraction of delivered nanoparticles (NPs) have been reported to traverse the cell membrane within 24 h. Consequently, higher doses are often necessitated, leading to increased toxicity concerns.
