Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound MRS 2578 that targets the human ADP-ribose glycohydrolase MacroD1 inhibited Semliki Forest virus production as well as viral RNA replication and replicase protein expression. The inhibitor was similarly active in alphavirus -replication systems, indicating that it targets the viral RNA replication stage.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597763 | PMC |
| http://dx.doi.org/10.1128/AAC.01398-21 | DOI Listing |
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