Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to β-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced β-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced β-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597773 | PMC |
| http://dx.doi.org/10.1128/AAC.01482-21 | DOI Listing |
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