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Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure. | LitMetric

Amyloidosis: A Rare Cause of Severe Cholestasis and Acute Liver Failure.

ACG Case Rep J

Department of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.

Published: December 2020

AI Article Synopsis

  • Hepatic involvement in light chain-associated amyloidosis usually occurs, but noticeable symptoms are rare and hepatomegaly is often the main sign.
  • A unique case involved a 48-year-old man from China who presented with jaundice and noncirrhotic portal hypertension, experiencing rapid liver failure without hepatomegaly.
  • This case highlights a specific instance of liver failure caused by systemic light chain-associated amyloidosis linked to multiple myeloma, emphasizing the variability of symptoms in such conditions.

Article Abstract

Although hepatic involvement in light chain-associated amyloidosis is common, clinical manifestations of hepatic amyloidosis are rare. In most cases, hepatomegaly serves as a clue to diagnosis. We report a unique case of a 48-year-old man from China with jaundice and noncirrhotic portal hypertension, with rapidly progressive liver failure, in the absence of hepatomegaly, secondary to systemic light chain-associated amyloidosis associated with multiple myeloma.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483873PMC
http://dx.doi.org/10.14309/crj.0000000000000479DOI Listing

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