AI Article Synopsis
- Tocilizumab (TCZ) is a monoclonal antibody that targets IL-6 signaling and is commonly used for autoimmune diseases, with some rare cases of hair growth changes reported.
- A 21-year-old woman with alopecia areata (AA) experienced improvement in her hair loss while being treated with TCZ for her eye condition called posterior uveitis.
- This case suggests that TCZ may positively affect AA by disrupting IL-6 signaling, which plays a role in hair loss and regrowth.
Article Abstract
Introduction: Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ.
Case Presentation: Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis.
Discussion: Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436663 | PMC |
| http://dx.doi.org/10.1159/000516300 | DOI Listing |
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