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Anti-inflammatory effects and enhancing immune response of freshwater hybrid catfish oil in RAW264.7 cells. | LitMetric

Anti-inflammatory effects and enhancing immune response of freshwater hybrid catfish oil in RAW264.7 cells.

Exp Ther Med

Center of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, Chiang Mai 50290, Thailand.

Published: November 2021

AI Article Synopsis

Article Abstract

The present study assessed the effect of freshwater hybrid catfish oil (FFO) on the inflammatory status of lipopolysaccharide (LPS)-stimulated RAW264.7 cells and investigated the underlying mechanisms. RAW264.7 cells were supplemented with various concentrations [0.125-2% in 0.5% propylene glycol (v/v)] of FFO with or without LPS (1 µg/ml) for 24 h. Inflammatory cytokines and mediators were quantified using ELISA and reverse transcription-quantitative PCR. The results revealed that FFO treatment inhibited the secretion and mRNA expression of the pro-inflammatory cytokines IL-6, IL-1β, TNF-α. In line with this, FFO suppressed the expression and secretion of the inflammatory mediators cyclooxygenase-2 and prostaglandin E2. FFO also reduced apoptotic body formation and DNA damage. Correspondingly, FFO enhanced the immune response by modulating the cell cycle regulators p53, cyclin D2 and cyclin E2. Accordingly, FFO may be developed as a nutraceutical product to prevent inflammation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453337PMC
http://dx.doi.org/10.3892/etm.2021.10657DOI Listing

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