Correlation between Mutations and Tumor Mutation Burden in Gastric Cancer.

Background: It has been shown that low-density lipoprotein receptor-related protein 1B () mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between mutations and TMB in gastric cancer needs further study. This study is aimed at exploring the relationship between mutations and TMB in gastric cancer.

Methods: Mutation frequency profiles of the genes in patients with gastric cancer in TCGA-STAD dataset were analyzed by bioinformatics analysis. The relationship among mutations, TMB, and patient clinical features in gastric cancer was investigated by the chi-square test. The TMB prediction capacity based on mutation status was evaluated by ROC curves.

Results: is one of the top 10 genes with high gene mutation frequency in gastric cancer. The mutation status of in gastric cancer patients was significantly correlated with age and and mutation status. The result of ROC curve analysis revealed that the mutation status of could be considered as an indicator of the degree of TMB in patients with gastric cancer.

Conclusion: This study presented the relationship between TMB and mutations in gastric cancer, providing a novel perspective for gastric cancer prognosis and therapy.