AI Article Synopsis
- Ichthyosis uteri is an extremely rare condition where the endometrial surface is entirely replaced by stratified squamous epithelium, typically considered benign.
- This condition can be associated with both benign and malignant conditions, including cervical squamous cell carcinoma, suggesting that significant cervical issues might be present when such changes are noted in endometrial samples.
- Initially linked to iatrogenic causes, similar epithelial changes have also been documented in various inflammatory endometrial conditions.
Article Abstract
Unlabelled: Ichthyosis uteri is an exceedingly rare condition in which the entire surface of the endometrium is replaced by stratified squamous epithelium. It is a benign lesion and its association with benign and malignant conditions has been reported in the literature (Bewtra, Xie, Hunter, Jurgensen (Arch Pathol Lab Med 29:e124-e125, 2005)). Originally described as an endometrial response to iatrogenically introduced caustic substances, similar changes have since been described in association with a variety of inflammatory conditions of the endometrium. It is concluded that a squamous cell carcinoma of the cervix extended proximally into the endometrium (Bagga, Jaswal, Datta, Mahajan (Indian J Pathol Microbiol 51:267-268, 2008)). The possibility of significant cervical pathology should be considered when plaques of squamous epithelium with low-grade dysplastic changes are identified in an endometrial biopsy or curettage.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13224-021-01472-3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440718 | PMC |
| http://dx.doi.org/10.1007/s13224-021-01472-3 | DOI Listing |
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