AI Article Synopsis
- The study highlights the underexplored potential of peptide strands to create complex entangled structures, mainly focusing on their interaction with Ag(I) ions and tripeptide ligands.
- The researchers successfully developed metal-peptide torus knots and links by manipulating the design of the amino acid side chains, showcasing the versatility of this chemistry.
- Additionally, the side chains' steric effects led to alterations in the torus structure, resulting in a unique infinite toroidal supercoil nanostructure.
Article Abstract
Despite the frequent occurrence of knotted frameworks in protein structures, the latent potential of peptide strands to form entangled structures is rarely discussed in peptide chemistry. Here we report the construction of highly entangled molecular topologies from Ag(I) ions and tripeptide ligands. The efficient entanglement of metal-peptide strands and the wide scope for design of the amino acid side chains in these ligands enabled the construction of metal-peptide 9 torus knots and 10 torus links. Moreover, steric control of the peptide side chain induced ring opening and twisting of the torus framework, which resulted in an infinite toroidal supercoil nanostructure.
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| http://dx.doi.org/10.1021/jacs.1c08094 | DOI Listing |
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Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Article Synopsis
- The study highlights the underexplored potential of peptide strands to create complex entangled structures, mainly focusing on their interaction with Ag(I) ions and tripeptide ligands.
- The researchers successfully developed metal-peptide torus knots and links by manipulating the design of the amino acid side chains, showcasing the versatility of this chemistry.
- Additionally, the side chains' steric effects led to alterations in the torus structure, resulting in a unique infinite toroidal supercoil nanostructure.
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